Version 5.4
Mus musculus Gene: Slc16a3
Summary
InnateDB Gene IDBG-214918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc16a3
Gene Name solute carrier family 16 (monocarboxylic acid transporters), member 3
Synonyms Mct3; Mct4
Species Mus musculus
Ensembl Gene ENSMUSG00000025161
Encoded Proteins
IDBP-214920
solute carrier family 16 (monocarboxylic acid transporters), member 3
IDBP-214924
solute carrier family 16 (monocarboxylic acid transporters), member 3
IDBP-536004
solute carrier family 16 (monocarboxylic acid transporters), member 3
IDBP-536039
solute carrier family 16 (monocarboxylic acid transporters), member 3
IDBP-536574
solute carrier family 16 (monocarboxylic acid transporters), member 3
IDBP-624551
solute carrier family 16 (monocarboxylic acid transporters), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141526:
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:120948480-120960868
Strand Forward strand
Band E2
Transcripts
ENSMUST00000070653 ENSMUSP00000068854
ENSMUST00000100130 ENSMUSP00000097706
ENSMUST00000154187 ENSMUSP00000122784
ENSMUST00000129473 ENSMUSP00000117275
ENSMUST00000133029 ENSMUSP00000115047
ENSMUST00000140467
ENSMUST00000134540
ENSMUST00000168579 ENSMUSP00000125846
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015293 symporter activity
GO:0015355 secondary active monocarboxylate transmembrane transporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0035879 plasma membrane lactate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141526
View Gene Order
ENSBTAG00000017461
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_188937
Metabolism pathway
REACT_211508
Basigin interactions pathway
REACT_253080
Pyruvate metabolism pathway
REACT_259683
Proton-coupled monocarboxylate transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_20515
Proton-coupled monocarboxylate transport pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_2071
Pyruvate metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28632
RefSeq NM_001038653 NM_001038654 NM_030696
OMIM
CCDS CCDS25761
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca