Version 5.4
Homo sapiens Gene: EPS8
Summary
InnateDB Gene IDBG-21563.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPS8
Gene Name epidermal growth factor receptor pathway substrate 8
Synonyms DFNB102
Species Homo sapiens
Ensembl Gene ENSG00000151491
Encoded Proteins
IDBP-21565
epidermal growth factor receptor pathway substrate 8
IDBP-586366
epidermal growth factor receptor pathway substrate 8
IDBP-599111
epidermal growth factor receptor pathway substrate 8
IDBP-597606
epidermal growth factor receptor pathway substrate 8
IDBP-585789
epidermal growth factor receptor pathway substrate 8
IDBP-603535
epidermal growth factor receptor pathway substrate 8
IDBP-592571
epidermal growth factor receptor pathway substrate 8
IDBP-591438
epidermal growth factor receptor pathway substrate 8
IDBP-593038
epidermal growth factor receptor pathway substrate 8
IDBP-592134
epidermal growth factor receptor pathway substrate 8
IDBP-596232
epidermal growth factor receptor pathway substrate 8
IDBP-593043
epidermal growth factor receptor pathway substrate 8
IDBP-585231
epidermal growth factor receptor pathway substrate 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22493489
EPS8 is a key regulator of the LPS-induced TLR4-MYD88 interaction and directly contributes to phagocytosis in macrophages. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22493489
[Mus musculus] Eps8 is a key regulator of the LPS-induced Tlr4-Myd88 interaction and directly contributes to phagocytosis in macrophages.
Entrez Gene
Summary This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:15620158-15882329
Strand Reverse strand
Band p12.3
Transcripts
ENST00000281172 ENSP00000281172
ENST00000508018
ENST00000543468 ENSP00000445985
ENST00000543523 ENSP00000441867
ENST00000543612 ENSP00000442388
ENST00000540613 ENSP00000441888
ENST00000542903 ENSP00000437806
ENST00000545610
ENST00000541465
ENST00000535734
ENST00000546261 ENSP00000438490
ENST00000536956 ENSP00000442883
ENST00000546311 ENSP00000445235
ENST00000535752 ENSP00000440591
ENST00000543363 ENSP00000444613
ENST00000536793 ENSP00000438668
ENST00000544064 ENSP00000445815
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0048365 Rac GTPase binding
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008283 cell proliferation
GO:0008344 adult locomotory behavior
GO:0008360 regulation of cell shape
GO:0009967 positive regulation of signal transduction
GO:0010458 exit from mitosis
GO:0016310 phosphorylation
GO:0016601 Rac protein signal transduction
GO:0030832 regulation of actin filament length
GO:0031532 actin cytoskeleton reorganization
GO:0036336 dendritic cell migration
GO:0045087 innate immune response (InnateDB)
GO:0048149 behavioral response to ethanol
GO:0051016 barbed-end actin filament capping
GO:0051017 actin filament bundle assembly
GO:0051764 actin crosslink formation
GO:0070358 actin polymerization-dependent cell motility
Cellular Component
GO:0005938 cell cortex
GO:0014069 postsynaptic density
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0030426 growth cone
GO:0032420 stereocilium
GO:0032587 ruffle membrane
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015766
View Gene Order
ENSBTAG00000000369
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
erbb1_downstream_pathway
ErbB1 downstream signaling
cdc42_pathway
CDC42 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591160 Hs.609259
RefSeq NM_004447 XM_005253339 XM_005253340 XM_006719057
HUGO
OMIM
CCDS CCDS31753
HPRD 02563
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca