Version 5.4
Homo sapiens Gene: KDM8
Summary
InnateDB Gene IDBG-21691.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDM8
Gene Name lysine (K)-specific demethylase 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155666
Encoded Proteins
IDBP-21693
jumonji domain containing 5
IDBP-373356
jumonji domain containing 5
IDBP-750795
IDBP-747360
IDBP-747630
IDBP-754562
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:27203495-27221768
Strand Forward strand
Band p12.1
Transcripts
ENST00000286096 ENSP00000286096
ENST00000441782 ENSP00000398410
ENST00000568792
ENST00000567366
ENST00000567735 ENSP00000455463
ENST00000562269
ENST00000563571
ENST00000569329 ENSP00000456107
ENST00000568965 ENSP00000456901
ENST00000564961
ENST00000567785
ENST00000563881
ENST00000562733 ENSP00000454215
ENST00000569592
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0046872 metal ion binding
GO:0051864 histone demethylase activity (H3-K36 specific)
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0055114 oxidation-reduction process
GO:0070544 histone H3-K36 demethylation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030752
View Gene Order
ENSBTAG00000019530
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 79831
UniGene Hs.145717
RefSeq NM_001145348 NM_024773 XM_006721092 XM_006721093
HUGO HGNC:25840
OMIM 611917
CCDS CCDS10627 CCDS45448
HPRD 07836
IMGT
EMBL
GenPept
RNA Seq Atlas 79831

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca