Homo sapiens Gene: PIK3C2G | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-21909.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PIK3C2G | ||||||||||||||||||||||
Gene Name | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma | ||||||||||||||||||||||
Synonyms | PI3K-C2-gamma; PI3K-C2GAMMA | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000139144 | ||||||||||||||||||||||
Encoded Proteins |
phosphoinositide-3-kinase, class 2, gamma polypeptide
phosphoinositide-3-kinase, class 2, gamma polypeptide
phosphoinositide-3-kinase, class 2, gamma polypeptide
phosphoinositide-3-kinase, class 2, gamma polypeptide
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
phosphoinositide-3-kinase, class 2, gamma polypeptide
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined. [provided by RefSeq, Jul 2008] The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:18247614-18648416 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | p12.3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Synthesis of PIPs at the plasma membrane pathway
Synthesis of PIPs at the Golgi membrane pathway
Metabolism of lipids and lipoproteins pathway
PI Metabolism pathway
Phospholipid metabolism pathway
Metabolism pathway
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KEGG |
Inositol phosphate metabolism pathway
Phosphatidylinositol signaling system pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 5288 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_001288772 NM_001288774 NM_004570 XM_005253393 XM_006719088 | ||||||||||||||||||||||
HUGO | HGNC:8973 | ||||||||||||||||||||||
OMIM | 609001 | ||||||||||||||||||||||
CCDS | CCDS44839 CCDS73452 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC087236 AC087240 AC091815 AC092851 AJ000008 BC130277 CH471094 | ||||||||||||||||||||||
GenPept | AAI30278 CAA03853 EAW96387 | ||||||||||||||||||||||
RNA Seq Atlas | 5288 | ||||||||||||||||||||||