Version 5.4
Homo sapiens Gene: SLCO1B3
Summary
InnateDB Gene IDBG-22433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLCO1B3
Gene Name solute carrier organic anion transporter family, member 1B3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111700
Encoded Proteins
IDBP-22435
solute carrier organic anion transporter family, member 1B3
IDBP-22437
solute carrier organic anion transporter family, member 1B3
IDBP-598946
solute carrier organic anion transporter family, member 1B3
IDBP-593147
solute carrier organic anion transporter family, member 1B3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:20810702-20916911
Strand Forward strand
Band p12.2
Transcripts
ENST00000381545 ENSP00000370956
ENST00000261196 ENSP00000261196
ENST00000540853 ENSP00000442000
ENST00000545880
ENST00000544370 ENSP00000443225
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0008514 organic anion transmembrane transporter activity
Biological Process
GO:0006810 transport
GO:0008206 bile acid metabolic process
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0043252 sodium-independent organic anion transport
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_23988
Transport of organic anions pathway
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_11042
Recycling of bile acids and salts pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_111217
Metabolism pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.504966
RefSeq NM_019844
HUGO
OMIM
CCDS CCDS8684
HPRD 12021
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca