Version 5.4
Homo sapiens Gene: PLAG1
Summary
InnateDB Gene IDBG-22444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLAG1
Gene Name pleiomorphic adenoma gene 1
Synonyms PSA; SGPA; ZNF912
Species Homo sapiens
Ensembl Gene ENSG00000181690
Encoded Proteins
IDBP-22446
pleiomorphic adenoma gene 1
IDBP-370951
pleiomorphic adenoma gene 1
IDBP-370952
pleiomorphic adenoma gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:56160904-56211324
Strand Reverse strand
Band q12.1
Transcripts
ENST00000316981 ENSP00000325546
ENST00000429357 ENSP00000416537
ENST00000423799 ENSP00000404067
ENST00000522009
ENST00000519027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0022612 gland morphogenesis
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060252 positive regulation of glial cell proliferation
GO:0060736 prostate gland growth
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003282
View Gene Order
ENSBTAG00000004022
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.14968 Hs.607709 Hs.613902
RefSeq NM_001114634 NM_001114635 NM_002655 XM_005251260
HUGO
OMIM
CCDS CCDS47860 CCDS6165
HPRD 04321
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca