InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: INSR

Summary

InnateDB Gene

IDBG-22529.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INSR

Gene Name

insulin receptor

Synonyms

CD220; HHF5

Species

Homo sapiens

Ensembl Gene

ENSG00000171105

Encoded Proteins

IDBP-22531

insulin receptor

IDBP-22533

insulin receptor

IDBP-763535

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:7112255-7294034

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000341500	ENSP00000342838
ENST00000302850	ENSP00000303830
ENST00000597211
ENST00000600492	ENSP00000473170
ENST00000598216
ENST00000593970
ENST00000601099

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	135 [view]
Protein-Protein	132 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0005009	insulin-activated receptor activity
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031994	insulin-like growth factor I binding
GO:0031995	insulin-like growth factor II binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0043559	insulin binding
GO:0043560	insulin receptor substrate binding
GO:0051425	PTB domain binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001934	positive regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0005975	carbohydrate metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008544	epidermis development
GO:0009887	organ morphogenesis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019087	transformation of host cell by virus
GO:0023014	signal transduction by phosphorylation
GO:0030238	male sex determination
GO:0030335	positive regulation of cell migration
GO:0031017	exocrine pancreas development
GO:0032147	activation of protein kinase activity
GO:0032148	activation of protein kinase B activity
GO:0032869	cellular response to insulin stimulus
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0042593	glucose homeostasis
GO:0043410	positive regulation of MAPK cascade
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045740	positive regulation of DNA replication
GO:0045821	positive regulation of glycolytic process
GO:0045840	positive regulation of mitosis
GO:0045995	regulation of embryonic development
GO:0046326	positive regulation of glucose import
GO:0046777	protein autophosphorylation
GO:0048639	positive regulation of developmental growth
GO:0051290	protein heterotetramerization
GO:0051897	positive regulation of protein kinase B signaling
GO:0060267	positive regulation of respiratory burst
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005899	insulin receptor complex
GO:0005901	caveola
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome