InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSK

Summary

InnateDB Gene

IDBG-22594.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSK

Gene Name

c-src tyrosine kinase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000103653

Encoded Proteins

IDBP-22596

c-src tyrosine kinase

IDBP-377819

c-src tyrosine kinase

IDBP-746304

IDBP-745613

IDBP-744899

IDBP-745778

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 15749833

Plays a critical role in IL-1-induced NF-kappaB activation through the IKK complex

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:74782057-74803198

Strand

Forward strand

Band

q24.1

Transcripts

ENST00000220003	ENSP00000220003
ENST00000439220	ENSP00000414764
ENST00000569915	ENSP00000454640
ENST00000567123	ENSP00000457497
ENST00000563010
ENST00000568329
ENST00000569462	ENSP00000457714
ENST00000567571	ENSP00000454906
ENST00000563894
ENST00000567135
ENST00000566464
ENST00000569321
ENST00000564216
ENST00000562066

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	103 [view]
Protein-Protein	101 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding
GO:0070064	proline-rich region binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007420	brain development
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0010989	negative regulation of low-density lipoprotein particle clearance
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030168	platelet activation
GO:0031295	T cell costimulation
GO:0032715	negative regulation of interleukin-6 production
GO:0033673	negative regulation of kinase activity
GO:0034332	adherens junction organization
GO:0042997	negative regulation of Golgi to plasma membrane protein transport
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045779	negative regulation of bone resorption
GO:0046777	protein autophosphorylation
GO:0048709	oligodendrocyte differentiation
GO:0050765	negative regulation of phagocytosis
GO:0050852	T cell receptor signaling pathway
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0071375	cellular response to peptide hormone stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome