Version 5.4
Homo sapiens Gene: GGTLC2
Summary
InnateDB Gene IDBG-2267.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGTLC2
Gene Name gamma-glutamyltransferase light chain 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100121
Encoded Proteins
IDBP-365689
gamma-glutamyltransferase light chain 2
IDBP-478052
gamma-glutamyltransferase light chain 2
IDBP-810752
gamma-glutamyltransferase light chain 2
IDBP-810753
gamma-glutamyltransferase light chain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC2, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:22644475-22647903
Strand Forward strand
Band q11.22
Transcripts
ENST00000417145
ENST00000448514 ENSP00000415676
ENST00000480559 ENSP00000419751
ENST00000613850 ENSP00000478615
ENST00000618722 ENSP00000483019
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003840 gamma-glutamyltransferase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0019370 leukotriene biosynthetic process
Cellular Component
GO:0031362 anchored component of external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt Q14390
TrEMBL
UniProt Splice Variant
Entrez Gene 91227
UniGene
RefSeq NM_199127 XM_005261818 XM_006724366
HUGO HGNC:18596
OMIM 612339
CCDS CCDS13802
HPRD 09971
IMGT
EMBL AC002308 BC069534 D87002 EL736203 X98922
GenPept AAH69534 BAA20001 CAA67421
RNA Seq Atlas 91227

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca