InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP7A1

Summary

InnateDB Gene

IDBG-22670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP7A1

Gene Name

cytochrome P450, family 7, subfamily A, polypeptide 1

Synonyms

CP7A; CYP7; CYPVII

Species

Homo sapiens

Ensembl Gene

ENSG00000167910

Encoded Proteins

IDBP-22672

cytochrome P450, family 7, subfamily A, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:58490178-58500236

Strand

Reverse strand

Band

q12.1

Transcripts

ENST00000301645

ENSP00000301645

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008123	cholesterol 7-alpha-monooxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding

Biological Process

GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0006805	xenobiotic metabolic process
GO:0008206	bile acid metabolic process
GO:0016125	sterol metabolic process
GO:0042632	cholesterol homeostasis
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070857	regulation of bile acid biosynthetic process
GO:0071333	cellular response to glucose stimulus
GO:0071397	cellular response to cholesterol