InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGEF18

Summary

InnateDB Gene

IDBG-22691.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF18

Gene Name

Rho/Rac guanine nucleotide exchange factor (GEF) 18

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000104880

Encoded Proteins

IDBP-22693

Rho/Rac guanine nucleotide exchange factor (GEF) 18

IDBP-22695

Rho/Rac guanine nucleotide exchange factor (GEF) 18

IDBP-760181

IDBP-765866

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:7395113-7472477

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000319670	ENSP00000319200
ENST00000359920	ENSP00000352995
ENST00000594665	ENSP00000470729
ENST00000599752	ENSP00000471597
ENST00000595600

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity

Biological Process

GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway