Version 5.4
Homo sapiens Gene: CCL24
Summary
InnateDB Gene IDBG-22726.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL24
Gene Name chemokine (C-C motif) ligand 24
Synonyms Ckb-6; MPIF-2; MPIF2; SCYA24
Species Homo sapiens
Ensembl Gene ENSG00000106178
Encoded Proteins
IDBP-22728
chemokine (C-C motif) ligand 24
IDBP-379494
chemokine (C-C motif) ligand 24
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:75811665-75823356
Strand Reverse strand
Band q11.23
Transcripts
ENST00000222902 ENSP00000222902
ENST00000416943 ENSP00000400533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0008009 chemokine activity
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008360 regulation of cell shape
GO:0030335 positive regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0032855 positive regulation of Rac GTPase activity
GO:0045766 positive regulation of angiogenesis
GO:0048245 eosinophil chemotaxis
GO:0050729 positive regulation of inflammatory response
GO:2000418 positive regulation of eosinophil migration
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004814
View Gene Order
ENSBTAG00000026275
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.247838
RefSeq NM_002991
HUGO
OMIM
CCDS CCDS34670
HPRD 03931
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca