InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GCGR

Summary

InnateDB Gene

IDBG-227533.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCGR

Gene Name

glucagon receptor

Synonyms

GGR; GL-R

Species

Homo sapiens

Ensembl Gene

ENSG00000215644

Encoded Proteins

IDBP-227535

glucagon receptor

IDBP-758485

IDBP-761987

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:81804132-81814013

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000400723	ENSP00000383558
ENST00000570996	ENSP00000460976
ENST00000574283
ENST00000573428	ENSP00000458930
ENST00000571425
ENST00000572185

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004967	glucagon receptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0017046	peptide hormone binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0006112	energy reserve metabolic process
GO:0006887	exocytosis
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0008217	regulation of blood pressure
GO:0009755	hormone-mediated signaling pathway
GO:0042593	glucose homeostasis
GO:0042594	response to starvation
GO:0043547	positive regulation of GTPase activity
GO:0044281	small molecule metabolic process
GO:0070873	regulation of glycogen metabolic process
GO:0071377	cellular response to glucagon stimulus