Homo sapiens Gene: ABCC9

Summary
InnateDB Gene IDBG-23107.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol ABCC9
Gene Name ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms ABC37; ATFB12; CANTU; CMD1O; SUR2
Species Homo sapiens
Ensembl Gene ENSG00000069431
Encoded Proteins
IDBP-23109 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
IDBP-23111 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
IDBP-23113 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
IDBP-23115 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
IDBP-601657 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
IDBP-587160 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12: 21950335-22094336
Strand Reverse strand
Band p12.1
Transcripts
ENST00000261200  ENSP00000261200
ENST00000261201  ENSP00000261201
ENST00000345162  ENSP00000261202
ENST00000326684  ENSP00000317518
ENST00000544039  ENSP00000440521
ENST00000538350  ENSP00000442604
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein‑Protein  3
[view]
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0015459 potassium channel regulator activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0044325 ion channel binding
Biological Process
GO:0006810 transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0010107 potassium ion import
GO:0051607 defense response to virus
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0008282 ATP-sensitive potassium channel complex
GO:0016020 membrane
GO:0016021 integral to membrane
GO:0030017 sarcomere
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000030249 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000019294 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_15480 ABC-family proteins mediated transport
REACT_75775 ATP sensitive Potassium channels
KEGG
hsa02010  ABC transporters
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O60706 
TrEMBL G3V1N6 H0YFV4 Q8N4N7 Q8N9N1
UniProt Splice Variant
Entrez Gene 10060 
UniGene Hs.446050 Hs.619371 Hs.631170 Hs.732701
RefSeq NM_005691  NM_020297 
HUGO 60 
OMIM 601439
CCDS CCDS8693  CCDS8694 
HPRD 03258
IMGT
EMBL AC008250 AC084806 AF061289 AF061290 AF061291 AF061292 AF061293 AF061294 AF061295 AF061296 AF061297 AF061298 AF061299 AF061300 AF061301 AF061302 AF061303 AF061304 AF061305 AF061306 AF061307 AF061308 AF061309 AF061310 AF061311 AF061312 AF061313 AF061314 AF061315 AF061316 AF061317 AF061318 AF061319 AF061320 AF061321 AF061322 AF061323 AF061324 AK094171 BC033804 CH471094
GenPept AAC16057  AAC16058  AAH33804  BAC04300  EAW96452 
ImmGen ABCC9 (murine) 
RNA Seq Atlas 10060