Homo sapiens Gene: YWHAG | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-23145.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | YWHAG | ||||||||||||||||||||||||
Gene Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | ||||||||||||||||||||||||
Synonyms | 14-3-3GAMMA; PPP1R170 | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000170027 | ||||||||||||||||||||||||
Encoded Proteins |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008] This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100%% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 7:76326794-76359031 | ||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||
Band | q11.23 | ||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 347 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH |
TNFalpha pathway
Prolactin pathway
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REACTOME |
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Activation of BAD and translocation to mitochondria pathway
Translocation of GLUT4 to the plasma membrane pathway
Apoptosis pathway
Cell Cycle pathway
Activation of BH3-only proteins pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Intrinsic Pathway for Apoptosis pathway
Mitotic G2-G2/M phases pathway
Membrane Trafficking pathway
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KEGG |
Cell cycle pathway
Oocyte meiosis pathway
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INOH |
Wnt signaling pathway pathway
Insulin receptor signaling pathway
Fas signaling pathway pathway
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PID NCI |
IL3-mediated signaling events
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Cross-References | |||||||||||||||||||||||||
SwissProt | P61981 | ||||||||||||||||||||||||
TrEMBL | B4DHC4 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 7532 | ||||||||||||||||||||||||
UniGene | Hs.592470 Hs.706016 | ||||||||||||||||||||||||
RefSeq | NM_012479 | ||||||||||||||||||||||||
HUGO | HGNC:12852 | ||||||||||||||||||||||||
OMIM | 605356 | ||||||||||||||||||||||||
CCDS | CCDS5584 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AB024334 AC006388 AF142498 AK295029 BC020963 CR541904 CR541925 | ||||||||||||||||||||||||
GenPept | AAD48408 AAH20963 BAA85184 BAG58085 CAG46702 CAG46723 | ||||||||||||||||||||||||
RNA Seq Atlas | 7532 | ||||||||||||||||||||||||