Version 5.4
Homo sapiens Gene: ZBED1
Summary
InnateDB Gene IDBG-232096.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZBED1
Gene Name zinc finger, BED-type containing 1
Synonyms ALTE; DREF; hDREF; TRAMP
Species Homo sapiens
Ensembl Gene ENSG00000214717
Encoded Proteins
IDBP-40617
zinc finger, BED-type containing 1
IDBP-40619
zinc finger, BED-type containing 1
IDBP-40621
zinc finger, BED-type containing 1
IDBP-481653
zinc finger, BED-type containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]
This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5\' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:2486414-2500967
Strand Reverse strand
Band p22.33
Transcripts
ENST00000381223 ENSP00000370621
ENST00000381222 ENSP00000370620
ENST00000381218 ENSP00000370616
ENST00000461691 ENSP00000419148
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004803 transposase activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0000228 nuclear chromosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL C9JXP4
UniProt Splice Variant
Entrez Gene 9189
UniGene Hs.131452 Hs.601629
RefSeq NM_001171135 NM_001171136 NM_004729
HUGO HGNC:447
OMIM 300178
CCDS CCDS14118
HPRD 02170
IMGT
EMBL AC079176
GenPept
RNA Seq Atlas 9189

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca