InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KL

Summary

InnateDB Gene

IDBG-23283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

klotho

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000133116

Encoded Proteins

IDBP-23285

klotho

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:33016433-33066145

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000380099	ENSP00000369442
ENST00000487852

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004566	beta-glucuronidase activity
GO:0004871	signal transducer activity
GO:0005104	fibroblast growth factor receptor binding
GO:0005179	hormone activity
GO:0005499	vitamin D binding
GO:0005515	protein binding
GO:0008422	beta-glucosidase activity
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0002526	acute inflammatory response
GO:0005975	carbohydrate metabolic process
GO:0006112	energy reserve metabolic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007568	aging
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0030501	positive regulation of bone mineralization
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0055074	calcium ion homeostasis
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000058488

View Gene Order

ENSBTAG00000013984

Not yet available

Pathways

NETPATH

NetPath_8

Wnt pathway

REACTOME

KEGG

hsa00040

Pentose and glucuronate interconversions pathway

hsa00500

Starch and sucrose metabolism pathway

INOH

PID NCI

fgf_pathway

FGF signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.524953 Hs.601263 Hs.713758

RefSeq

NM_004795 XM_006719895

HUGO

OMIM

CCDS

CCDS9347

HPRD

05316

IMGT

EMBL

GenPept

RNA Seq Atlas