Version 5.4
Homo sapiens Gene: FCER2
Summary
InnateDB Gene IDBG-23316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCER2
Gene Name Fc fragment of IgE, low affinity II, receptor for (CD23)
Synonyms BLAST-2; CD23; CD23A; CLEC4J; FCE2; IGEBF
Species Homo sapiens
Ensembl Gene ENSG00000104921
Encoded Proteins
IDBP-23318
Fc fragment of IgE, low affinity II, receptor for (CD23)
IDBP-23320
Fc fragment of IgE, low affinity II, receptor for (CD23)
IDBP-762916
IDBP-761057
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:7688758-7702146
Strand Reverse strand
Band p13.2
Transcripts
ENST00000346664 ENSP00000264072
ENST00000360067 ENSP00000353178
ENST00000598803
ENST00000593418 ENSP00000472067
ENST00000597921 ENSP00000471974
ENST00000597312
ENST00000597934
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 6 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0019863 IgE binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0007219 Notch signaling pathway
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051712 positive regulation of killing of cells of other organism
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005540
View Gene Order
ENSBTAG00000004270
Not yet available
Pathways
NETPATH
REACTOME
REACT_111102
Signal Transduction pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_299
Signaling by NOTCH pathway
REACT_163910
NOTCH2 intracellular domain regulates transcription pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
INOH
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.465778
RefSeq NM_001207019 NM_001220500 NM_002002 XM_005272462 XM_006722687
HUGO
OMIM
CCDS CCDS12184
HPRD 01049
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca