InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TGFBR2

Summary

InnateDB Gene

IDBG-23359.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGFBR2

Gene Name

transforming growth factor, beta receptor II (70/80kDa)

Synonyms

AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TGFbeta-RII; TGFR-2

Species

Homo sapiens

Ensembl Gene

ENSG00000163513

Encoded Proteins

IDBP-23361

transforming growth factor, beta receptor II (70/80kDa)

IDBP-23363

transforming growth factor, beta receptor II (70/80kDa)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:30606502-30694142

Strand

Forward strand

Band

p24.1

Transcripts

ENST00000359013	ENSP00000351905
ENST00000295754	ENSP00000295754

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	84 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005026	transforming growth factor beta receptor activity, type II
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005539	glycosaminoglycan binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0034714	type III transforming growth factor beta receptor binding
GO:0046332	SMAD binding
GO:0046872	metal ion binding
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0001568	blood vessel development
GO:0001569	patterning of blood vessels
GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002088	lens development in camera-type eye
GO:0002651	positive regulation of tolerance induction to self antigen
GO:0002663	positive regulation of B cell tolerance induction
GO:0002666	positive regulation of T cell tolerance induction
GO:0006468	protein phosphorylation
GO:0006898	receptor-mediated endocytosis
GO:0006915	apoptotic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007182	common-partner SMAD protein phosphorylation
GO:0007224	smoothened signaling pathway
GO:0007369	gastrulation
GO:0007420	brain development
GO:0007507	heart development
GO:0007566	embryo implantation
GO:0007568	aging
GO:0007584	response to nutrient
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009612	response to mechanical stimulus
GO:0009749	response to glucose
GO:0009887	organ morphogenesis
GO:0010033	response to organic substance
GO:0010634	positive regulation of epithelial cell migration
GO:0014070	response to organic cyclic compound
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030324	lung development
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100	organ regeneration
GO:0032147	activation of protein kinase activity
GO:0035162	embryonic hemopoiesis
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0043011	myeloid dendritic cell differentiation
GO:0043415	positive regulation of skeletal muscle tissue regeneration
GO:0043627	response to estrogen
GO:0045766	positive regulation of angiogenesis
GO:0048545	response to steroid hormone
GO:0048565	digestive tract development
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0051138	positive regulation of NK T cell differentiation
GO:0051216	cartilage development
GO:0060021	palate development
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060425	lung morphogenesis
GO:0060433	bronchus development
GO:0060434	bronchus morphogenesis
GO:0060439	trachea morphogenesis
GO:0060440	trachea formation
GO:0060443	mammary gland morphogenesis
GO:0060463	lung lobe morphogenesis
GO:0070723	response to cholesterol
GO:1990086	lens fiber cell apoptotic process
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0070022	transforming growth factor beta receptor homodimeric complex