InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MTA1

Summary

InnateDB Gene

IDBG-23411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTA1

Gene Name

metastasis associated 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000182979

Encoded Proteins

IDBP-23413

metastasis associated 1

IDBP-295254

metastasis associated 1

IDBP-295253

metastasis associated 1

IDBP-378720

metastasis associated 1

IDBP-378726

metastasis associated 1

IDBP-378729

metastasis associated 1

IDBP-378730

metastasis associated 1

IDBP-378736

metastasis associated 1

IDBP-597408

metastasis associated 1

IDBP-596489

metastasis associated 1

IDBP-599464

metastasis associated 1

IDBP-585257

metastasis associated 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20699220

MTA1 binds to the MYD88 promoter to regulate LPS-induced NFkappa B signaling via MYD88-dependent signalling in murine macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 20699220

[Mus musculus] Mta1 binds to the Myd88 promoter to regulate LPS-induced NFkappa B signaling via Myd88-dependent signalling in murine macrophages.

Entrez Gene

Summary

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:105419820-105470729

Strand

Forward strand

Band

q32.33

Transcripts

ENST00000331320	ENSP00000333633
ENST00000406191	ENSP00000385702
ENST00000405646	ENSP00000384180
ENST00000435036	ENSP00000389425
ENST00000438610	ENSP00000393438
ENST00000424723	ENSP00000411493
ENST00000434050	ENSP00000394106
ENST00000426567	ENSP00000395371
ENST00000481012
ENST00000494026
ENST00000498644	ENSP00000448146
ENST00000490198
ENST00000469140
ENST00000481206
ENST00000494981	ENSP00000450269
ENST00000481635
ENST00000551236	ENSP00000450094
ENST00000550551	ENSP00000446480
ENST00000550808
ENST00000552286

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	93 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding