InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MEF2B

Summary

InnateDB Gene

IDBG-235890.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEF2B

Gene Name

myocyte enhancer factor 2B

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000213999

Encoded Proteins

IDBP-295491

myocyte enhancer factor 2B

IDBP-295497

myocyte enhancer factor 2B

IDBP-295495

myocyte enhancer factor 2B

IDBP-376451

myocyte enhancer factor 2B

IDBP-376459

myocyte enhancer factor 2B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (geneID:729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as geneID:4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on geneID:4207. [provided by RefSeq, Mar 2009] This gene represents numerous read-through transcripts that span GeneID:729991 and 100271849. Many read-through transcripts are predicted to be nonsense-mediated decay (NMD) candidates, and are thought to be non-coding. Some transcripts are predicted to be capable of translation reinitiation at a downstream AUG, resulting in expression of at least one isoform of myocyte enhancer factor 2B (MEF2B) from this read-through locus. At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is annotated on GeneID:100271849. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:19145568-19170289

Strand

Reverse strand

Band

p13.11

Transcripts

ENST00000409447	ENSP00000386784
ENST00000410050	ENSP00000386374
ENST00000409224	ENSP00000386480
ENST00000444486	ENSP00000390762
ENST00000424583	ENSP00000402154

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042826	histone deacetylase binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007517	muscle organ development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0030054	cell junction

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002345

View Gene Order

ENSBTAG00000001818

Not yet available

Pathways

NETPATH

REACTOME

REACT_21402

CDO in myogenesis pathway

REACT_111045

Developmental Biology pathway

REACT_21303

Myogenesis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.153629

RefSeq

NM_001145785 NM_005919

HUGO

OMIM

CCDS

CCDS46024 CCDS12394 CCDS46025

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas