Version 5.4
Homo sapiens Gene: GPD1L
Summary
InnateDB Gene IDBG-23626.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPD1L
Gene Name glycerol-3-phosphate dehydrogenase 1-like
Synonyms GPD1-L
Species Homo sapiens
Ensembl Gene ENSG00000152642
Encoded Proteins
IDBP-23628
glycerol-3-phosphate dehydrogenase 1-like
IDBP-369435
glycerol-3-phosphate dehydrogenase 1-like
IDBP-369444
glycerol-3-phosphate dehydrogenase 1-like
IDBP-369445
glycerol-3-phosphate dehydrogenase 1-like
IDBP-369447
glycerol-3-phosphate dehydrogenase 1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the conversion of sn-glycerol 3-phosphate to glycerone phosphate. The encoded protein is found in the cytoplasm, associated with the plasma membrane, where it binds the sodium channel, voltage-gated, type V, alpha subunit (SCN5A). Defects in this gene are a cause of Brugada syndrome type 2 (BRS2) as well as sudden infant death syndrome (SIDS). [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:32105689-32168713
Strand Forward strand
Band p22.3
Transcripts
ENST00000282541 ENSP00000282541
ENST00000429432 ENSP00000393861
ENST00000428684 ENSP00000392199
ENST00000425459 ENSP00000408770
ENST00000431009 ENSP00000416518
ENST00000474846
ENST00000496151
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0017080 sodium channel regulator activity
GO:0042803 protein homodimerization activity
GO:0044325 ion channel binding
GO:0051287 NAD binding
Biological Process
GO:0002027 regulation of heart rate
GO:0005975 carbohydrate metabolic process
GO:0006072 glycerol-3-phosphate metabolic process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006734 NADH metabolic process
GO:0010765 positive regulation of sodium ion transport
GO:0019432 triglyceride biosynthetic process
GO:0019674 NAD metabolic process
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046168 glycerol-3-phosphate catabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0055114 oxidation-reduction process
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0086005 ventricular cardiac muscle cell action potential
GO:0090038 negative regulation of protein kinase C signaling
GO:2000010 positive regulation of protein localization to cell surface
GO:2000649 regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009331 glycerol-3-phosphate dehydrogenase complex
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050627
View Gene Order
ENSBTAG00000009826
Not yet available
Pathways
NETPATH
REACTOME
REACT_120906
Synthesis of PA pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JM46
UniProt Splice Variant
Entrez Gene 23171
UniGene Hs.622121 Hs.82432
RefSeq NM_015141 XM_005264984 XM_006713068
HUGO HGNC:28956
OMIM 611778
CCDS CCDS33729
HPRD 10008
IMGT
EMBL AC094019
GenPept
RNA Seq Atlas 23171

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca