Version 5.4
Homo sapiens Gene: CLEC4M
Summary
InnateDB Gene IDBG-23635.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC4M
Gene Name C-type lectin domain family 4, member M
Synonyms CD209L; CD299; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN
Species Homo sapiens
Ensembl Gene ENSG00000104938
Encoded Proteins
IDBP-23637
C-type lectin domain family 4, member M
IDBP-23639
C-type lectin domain family 4, member M
IDBP-23645
C-type lectin domain family 4, member M
IDBP-23649
C-type lectin domain family 4, member M
IDBP-242182
C-type lectin domain family 4, member M
IDBP-760547
IDBP-762153
IDBP-765541
IDBP-764326
IDBP-763023
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:7763149-7769605
Strand Forward strand
Band p13.2
Transcripts
ENST00000327325 ENSP00000316228
ENST00000359059 ENSP00000351954
ENST00000334806 ENSP00000335228
ENST00000248228 ENSP00000248228
ENST00000394122 ENSP00000377680
ENST00000596707 ENSP00000470137
ENST00000601089
ENST00000599333
ENST00000595751 ENSP00000470286
ENST00000598879
ENST00000595496 ENSP00000470132
ENST00000596363 ENSP00000471125
ENST00000602143
ENST00000597522 ENSP00000471132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005537 mannose binding
GO:0030246 carbohydrate binding
GO:0030369 ICAM-3 receptor activity
GO:0042605 peptide antigen binding
GO:0046790 virion binding
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0007159 leukocyte cell-cell adhesion
GO:0009988 cell-cell recognition
GO:0010468 regulation of gene expression
GO:0019048 modulation by virus of host morphology or physiology
GO:0019062 virion attachment to host cell
GO:0019079 viral genome replication
GO:0019882 antigen processing and presentation
GO:0030193 regulation of blood coagulation
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response
GO:0046968 peptide antigen transport
GO:0075733 intracellular transport of virus
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.421437 Hs.613731
RefSeq NM_001144904 NM_001144905 NM_001144906 NM_001144907 NM_001144908 NM_001144909 NM_001144910 NM_001144911 NM_014257 XM_006722611 XM_006722614 XM_006722615
HUGO
OMIM
CCDS CCDS12187 CCDS59346 CCDS59347 CCDS59348
HPRD 12060
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca