InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGA1

Summary

InnateDB Gene

IDBG-236376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA1

Gene Name

integrin, alpha 1

Synonyms

CD49a; VLA1

Species

Homo sapiens

Ensembl Gene

ENSG00000213949

Encoded Proteins

IDBP-20218

integrin, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:52787896-52959210

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000282588	ENSP00000282588
ENST00000504086
ENST00000513737
ENST00000514262
ENST00000509049
ENST00000504669
ENST00000506275

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0019903	protein phosphatase binding
GO:0046872	metal ion binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006936	muscle contraction
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042311	vasodilation
GO:0043525	positive regulation of neuron apoptotic process
GO:0045123	cellular extravasation
GO:0048812	neuron projection morphogenesis
GO:0060326	cell chemotaxis

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043204	perikaryon
GO:0045121	membrane raft
GO:0045178	basal part of cell
GO:0070062	extracellular vesicular exosome