Version 5.4
Homo sapiens Gene: HBE1
Summary
InnateDB Gene IDBG-236544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HBE1
Gene Name hemoglobin, epsilon 1
Synonyms HBE
Species Homo sapiens
Ensembl Gene ENSG00000213931
Encoded Proteins
IDBP-26447
hemoglobin, epsilon 1
IDBP-26449
hemoglobin, epsilon 1
IDBP-236546
hemoglobin, epsilon 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5\'-epsilon - G-gamma - A-gamma - delta - beta-3\' [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:5268345-5505617
Strand Reverse strand
Band p15.4
Transcripts
ENST00000380237 ENSP00000369586
ENST00000292896 ENSP00000292896
ENST00000396895 ENSP00000380104
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005344 oxygen transporter activity
GO:0005506 iron ion binding
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0031721 hemoglobin alpha binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007596 blood coagulation
GO:0015671 oxygen transport
GO:0051291 protein heterooligomerization
Cellular Component
GO:0005829 cytosol
GO:0005833 hemoglobin complex
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052187
View Gene Order
ENSBTAG00000037815
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655195
RefSeq NM_005330
HUGO
OMIM
CCDS CCDS7756
HPRD 00788
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca