Version 5.4
Homo sapiens Gene: LTB4R
Summary
InnateDB Gene IDBG-236774.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTB4R
Gene Name leukotriene B4 receptor
Synonyms BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1; P2RY7; P2Y7
Species Homo sapiens
Ensembl Gene ENSG00000213903
Encoded Proteins
IDBP-3814
leukotriene B4 receptor
IDBP-236776
leukotriene B4 receptor
IDBP-236778
leukotriene B4 receptor
IDBP-599212
leukotriene B4 receptor
IDBP-583898
leukotriene B4 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20959460
LTB4R (BLT1) is a high-affinity leukotriene B4 (LTB4) receptor that is expressed in a variety of immune cells such as neutrophils, macrophages and dendritic cells. LTB4-LTB4R signaling plays a pivotal role in macrophage phagocytosis and innate immunity.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24311450-24318036
Strand Forward strand
Band q12
Transcripts
ENST00000345363 ENSP00000307445
ENST00000396789 ENSP00000380008
ENST00000396782 ENSP00000380002
ENST00000553481 ENSP00000450457
ENST00000556141 ENSP00000451929
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001632 leukotriene B4 receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004974 leukotriene receptor activity
Biological Process
GO:0006928 cellular component movement
GO:0006936 muscle contraction
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046908
View Gene Order
ENSBTAG00000010238
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18302
Leukotriene receptors pathway
REACT_18352
Eicosanoid ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567248 Hs.655431
RefSeq NM_001143919 NM_181657
HUGO
OMIM
CCDS CCDS9626
HPRD 03320
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca