Version 5.4
Homo sapiens Gene: PTPN12
Summary
InnateDB Gene IDBG-23713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN12
Gene Name protein tyrosine phosphatase, non-receptor type 12
Synonyms PTP-PEST; PTPG1
Species Homo sapiens
Ensembl Gene ENSG00000127947
Encoded Proteins
IDBP-23715
protein tyrosine phosphatase, non-receptor type 12
IDBP-295606
protein tyrosine phosphatase, non-receptor type 12
IDBP-380034
protein tyrosine phosphatase, non-receptor type 12
IDBP-380037
protein tyrosine phosphatase, non-receptor type 12
IDBP-380040
protein tyrosine phosphatase, non-receptor type 12
IDBP-380043
protein tyrosine phosphatase, non-receptor type 12
IDBP-380050
protein tyrosine phosphatase, non-receptor type 12
IDBP-380052
protein tyrosine phosphatase, non-receptor type 12
IDBP-475124
protein tyrosine phosphatase, non-receptor type 12
IDBP-475780
protein tyrosine phosphatase, non-receptor type 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:77537275-77640071
Strand Forward strand
Band q11.23
Transcripts
ENST00000248594 ENSP00000248594
ENST00000407343 ENSP00000385079
ENST00000433369 ENSP00000404050
ENST00000435495 ENSP00000397991
ENST00000415482 ENSP00000392429
ENST00000418110 ENSP00000392526
ENST00000440186 ENSP00000413449
ENST00000447995 ENSP00000397364
ENST00000460731
ENST00000523952 ENSP00000428735
ENST00000522115 ENSP00000430726
ENST00000481154
ENST00000494248
ENST00000464313
ENST00000520947
ENST00000519553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 87 [view]
Protein-Protein 87 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0017124 SH3 domain binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030054 cell junction
GO:0042995 cell projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028771
View Gene Order
ENSBTAG00000003825
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q05209
TrEMBL
UniProt Splice Variant
Entrez Gene 5782
UniGene Hs.61812 Hs.708621
RefSeq NM_001131009 NM_001131008 NM_002835 XM_005250518 XM_006716074
HUGO HGNC:9645
OMIM 600079
CCDS CCDS47620 CCDS47619 CCDS5592
HPRD 02513
IMGT
EMBL AB209524 AC006451 AK289573 AK296764 BC050008 CH236949 CH471091 D13380 M93425 S69184
GenPept AAA36529 AAB30047 AAH50008 AAQ96881 BAA02648 BAD92761 BAF82262 BAG59344 EAL24198 EAW77036 EAW77037
RNA Seq Atlas 5782

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca