InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DVL2

Summary

InnateDB Gene

IDBG-23761.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DVL2

Gene Name

dishevelled, dsh homolog 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000004975

Encoded Proteins

IDBP-23765

dishevelled, dsh homolog 2 (Drosophila)

IDBP-758265

IDBP-760641

IDBP-758284

IDBP-762491

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40%% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:7225341-7234545

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000005340	ENSP00000005340
ENST00000575086	ENSP00000458465
ENST00000576285
ENST00000574642
ENST00000572285
ENST00000576840
ENST00000575458	ENSP00000459797
ENST00000573354
ENST00000575756	ENSP00000459991
ENST00000576439
ENST00000571745
ENST00000576949
ENST00000577154
ENST00000574591
ENST00000574143	ENSP00000458209

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	125 [view]
Protein-Protein	123 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:0043621	protein self-association

Biological Process

GO:0001843	neural tube closure
GO:0001934	positive regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007379	segment specification
GO:0007507	heart development
GO:0016055	Wnt signaling pathway
GO:0021535	cell migration in hindbrain
GO:0022007	convergent extension involved in neural plate elongation
GO:0034613	cellular protein localization
GO:0035282	segmentation
GO:0035329	hippo signaling
GO:0035556	intracellular signal transduction
GO:0035567	non-canonical Wnt signaling pathway
GO:0043507	positive regulation of JUN kinase activity
GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060026	convergent extension
GO:0060029	convergent extension involved in organogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0030136	clathrin-coated vesicle
GO:0031410	cytoplasmic vesicle
GO:0045177	apical part of cell
GO:0045334	clathrin-coated endocytic vesicle