Version 5.4
Homo sapiens Gene: AFP
Summary
InnateDB Gene IDBG-23783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFP
Gene Name alpha-fetoprotein
Synonyms AFPD; FETA; HPAFP
Species Homo sapiens
Ensembl Gene ENSG00000081051
Encoded Proteins
IDBP-23785
alpha-fetoprotein
IDBP-238818
alpha-fetoprotein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:73431138-73456174
Strand Forward strand
Band q13.3
Transcripts
ENST00000226359 ENSP00000226359
ENST00000395792 ENSP00000379138
ENST00000513720
ENST00000515675
ENST00000508838
ENST00000514279
ENST00000506820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0001542 ovulation from ovarian follicle
GO:0006810 transport
GO:0019953 sexual reproduction
GO:0042448 progesterone metabolic process
GO:0060395 SMAD protein signal transduction
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054932
View Gene Order
ENSBTAG00000017131
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
p53downstreampathway
Direct p53 effectors
reg_gr_pathway
Glucocorticoid receptor regulatory network
p73pathway
p73 transcription factor network
Cross-References
SwissProt P02771
TrEMBL
UniProt Splice Variant
Entrez Gene 174
UniGene Hs.518808 Hs.707532
RefSeq NM_001134
HUGO HGNC:317
OMIM 104150
CCDS CCDS3556
HPRD 00074
IMGT
EMBL AK314817 BC027881 M10949 M10950 M16110 V01514 Z19532
GenPept AAA51674 AAA51675 AAB58754 AAH27881 BAG37340 CAA24758 CAA79592
RNA Seq Atlas 174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca