InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GABARAP

Summary

InnateDB Gene

IDBG-23900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABARAP

Gene Name

GABA(A) receptor-associated protein

Synonyms

ATG8A; GABARAP-a; MM46

Species

Homo sapiens

Ensembl Gene

ENSG00000170296

Encoded Proteins

IDBP-23902

GABA(A) receptor-associated protein

IDBP-759598

IDBP-759547

IDBP-762006

IDBP-760032

IDBP-760782

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23427251

[Mus musculus] Gabarap deficient mice are more susceptible to sepsis due to enhanced inflammasome activation.

Entrez Gene

Summary

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:7240014-7242770

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000302386	ENSP00000306866
ENST00000577035	ENSP00000460855
ENST00000573928	ENSP00000458476
ENST00000571129	ENSP00000461882
ENST00000570856	ENSP00000460489
ENST00000571253	ENSP00000459345

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	67 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0048487	beta-tubulin binding
GO:0050811	GABA receptor binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000226	microtubule cytoskeleton organization
GO:0006605	protein targeting
GO:0006914	autophagy
GO:0007268	synaptic transmission
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0015031	protein transport

Cellular Component

GO:0000139	Golgi membrane
GO:0000421	autophagic vacuole membrane
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005776	autophagic vacuole
GO:0005790	smooth endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0005930	axoneme
GO:0015629	actin cytoskeleton
GO:0031410	cytoplasmic vesicle
GO:0044297	cell body
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000018567

View Gene Order

ENSBTAG00000014883

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04140

Regulation of autophagy pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_007278

HUGO

OMIM

CCDS

CCDS11092

HPRD

05496

IMGT

EMBL

GenPept

RNA Seq Atlas