Version 5.4
Homo sapiens Gene: PSTPIP1
Summary
InnateDB Gene IDBG-24106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSTPIP1
Gene Name proline-serine-threonine phosphatase interacting protein 1
Synonyms CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP
Species Homo sapiens
Ensembl Gene ENSG00000140368
Encoded Proteins
IDBP-24108
proline-serine-threonine phosphatase interacting protein 1
IDBP-583727
proline-serine-threonine phosphatase interacting protein 1
IDBP-601423
proline-serine-threonine phosphatase interacting protein 1
IDBP-595619
proline-serine-threonine phosphatase interacting protein 1
IDBP-599759
proline-serine-threonine phosphatase interacting protein 1
IDBP-592380
proline-serine-threonine phosphatase interacting protein 1
IDBP-599045
proline-serine-threonine phosphatase interacting protein 1
IDBP-603476
proline-serine-threonine phosphatase interacting protein 1
IDBP-601652
proline-serine-threonine phosphatase interacting protein 1
IDBP-587504
proline-serine-threonine phosphatase interacting protein 1
IDBP-583839
proline-serine-threonine phosphatase interacting protein 1
IDBP-598029
proline-serine-threonine phosphatase interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17964261
Activates MEFV by binding to the B-Box domain of MEFV and unmasking its PYD domain
PMID 17964261
Enhances binding of MEFV to PYCARD
PMID 14595025
Tyrosine phosphorylation of PSTPIP1 significantly enhances its interaction with MEFV
Entrez Gene
Summary The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:76993359-77037332
Strand Forward strand
Band q24.3
Transcripts
ENST00000379595 ENSP00000368914
ENST00000558407 ENSP00000453268
ENST00000559785 ENSP00000452986
ENST00000558012 ENSP00000452746
ENST00000560223 ENSP00000454118
ENST00000559795
ENST00000559750 ENSP00000453531
ENST00000560621
ENST00000560377
ENST00000560796 ENSP00000454127
ENST00000559161 ENSP00000453372
ENST00000559295 ENSP00000452743
ENST00000559859 ENSP00000453218
ENST00000559856 ENSP00000453382
ENST00000561315
ENST00000557995
ENST00000558870 ENSP00000452779
ENST00000560064
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0019903 protein phosphatase binding
Biological Process
GO:0006897 endocytosis
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0055114 oxidation-reduction process
Cellular Component
GO:0001725 stress fiber
GO:0001931 uropod
GO:0005826 actomyosin contractile ring
GO:0005829 cytosol
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0032154 cleavage furrow
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032322
View Gene Order
ENSBTAG00000021144
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_75808
The NLRP3 inflammasome pathway
REACT_75900
Inflammasomes pathway
REACT_6802
Innate Immune System pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_6900
Immune System pathway
KEGG
hsa04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.129758
RefSeq NM_003978 XM_006720736 XM_006720738
HUGO
OMIM
CCDS CCDS45312
HPRD 05891
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca