InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLX1B

Summary

InnateDB Gene

IDBG-24268.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLX1B

Gene Name

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000181625

Encoded Proteins

IDBP-24270

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

IDBP-24274

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

IDBP-753201

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010] This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:29454501-29458219

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000330181	ENSP00000328940
ENST00000351581	ENSP00000335316
ENST00000565219
ENST00000567248	ENSP00000456372
ENST00000566424

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008821	crossover junction endodeoxyribonuclease activity
GO:0017108	5'-flap endonuclease activity
GO:0046872	metal ion binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing

Cellular Component

GO:0033557

Slx1-Slx4 complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000059772

View Gene Order

ENSBTAG00000008633

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_024044 NM_178044 XM_006726622 XM_006726623

HUGO

OMIM

CCDS

CCDS10648 CCDS10649

HPRD

14673

IMGT

EMBL

GenPept

RNA Seq Atlas