InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GSTM2

Summary

InnateDB Gene

IDBG-243147.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTM2

Gene Name

glutathione S-transferase mu 2 (muscle)

Synonyms

GST4; GSTM; GSTM2-2; GTHMUS

Species

Homo sapiens

Ensembl Gene

ENSG00000213366

Encoded Proteins

IDBP-100878

glutathione S-transferase mu 2 (muscle)

IDBP-100880

glutathione S-transferase mu 2 (muscle)

IDBP-100884

glutathione S-transferase mu 2 (muscle)

IDBP-100886

glutathione S-transferase mu 2 (muscle)

IDBP-387563

glutathione S-transferase mu 2 (muscle)

IDBP-387564

glutathione S-transferase mu 2 (muscle)

IDBP-602279

glutathione S-transferase mu 2 (muscle)

IDBP-586815

glutathione S-transferase mu 2 (muscle)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual\'s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:109668022-109709551

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000369831	ENSP00000358846
ENST00000241337	ENSP00000241337
ENST00000369829	ENSP00000358844
ENST00000369827	ENSP00000358842
ENST00000442650	ENSP00000416883
ENST00000414179	ENSP00000404662
ENST00000464206
ENST00000481656
ENST00000476040
ENST00000467579	ENSP00000435157
ENST00000460717	ENSP00000435910
ENST00000472225
ENST00000496578
ENST00000568786
ENST00000624726

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0018916	nitrobenzene metabolic process
GO:0042178	xenobiotic catabolic process
GO:0044281	small molecule metabolic process
GO:0055119	relaxation of cardiac muscle
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0070458	cellular detoxification of nitrogen compound
GO:0071313	cellular response to caffeine
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016529	sarcoplasmic reticulum
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_6926

Glutathione conjugation pathway

REACT_6959

Phase II conjugation pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

hsa00480

Glutathione metabolism pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

hsa00982

Drug metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.551627 Hs.595978

RefSeq

NM_000848 NM_001142368

HUGO

OMIM

CCDS

CCDS44192 CCDS808

HPRD

00710

IMGT

EMBL

GenPept

RNA Seq Atlas