Version 5.4
Homo sapiens Gene: ART1
Summary
InnateDB Gene IDBG-24341.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ART1
Gene Name ADP-ribosyltransferase 1
Synonyms ART2; ARTC1; CD296; RT6
Species Homo sapiens
Ensembl Gene ENSG00000129744
Encoded Proteins
IDBP-24343
ADP-ribosyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:3645128-3664416
Strand Forward strand
Band p15.4
Transcripts
ENST00000250693 ENSP00000250693
ENST00000529556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0045087 innate immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0031225 anchored component of membrane
GO:0033017 sarcoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030996
View Gene Order
ENSBTAG00000006345
Not yet available
Pathways
NETPATH
REACTOME
REACT_115574
Alpha-defensins pathway
REACT_115846
Defensins pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P52961
TrEMBL
UniProt Splice Variant
Entrez Gene 417
UniGene Hs.382188
RefSeq NM_004314 XM_005252933
HUGO HGNC:723
OMIM 601625
CCDS CCDS7744
HPRD
IMGT
EMBL AJ291430 BC069102 BC111729 CH471158 S74683
GenPept AAB32387 AAH69102 AAI11730 CAC69964 EAX02559
RNA Seq Atlas 417

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca