Version 5.4
Homo sapiens Gene: ARFGEF1
Summary
InnateDB Gene IDBG-24344.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARFGEF1
Gene Name ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
Synonyms ARFGEP1; BIG1; P200
Species Homo sapiens
Ensembl Gene ENSG00000066777
Encoded Proteins
IDBP-24346
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
IDBP-484464
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
IDBP-485187
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
IDBP-477549
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
IDBP-479411
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
IDBP-477416
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:67173512-67343677
Strand Reverse strand
Band q13.2
Transcripts
ENST00000262215 ENSP00000262215
ENST00000520381 ENSP00000428429
ENST00000522878
ENST00000518290
ENST00000517955
ENST00000518789 ENSP00000429560
ENST00000518230 ENSP00000430891
ENST00000517631 ENSP00000429138
ENST00000519436 ENSP00000429002
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0017022 myosin binding
GO:0034237 protein kinase A regulatory subunit binding
Biological Process
GO:0006887 exocytosis
GO:0007030 Golgi organization
GO:0010256 endomembrane system organization
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0030837 negative regulation of actin filament polymerization
GO:0032012 regulation of ARF protein signal transduction
GO:0034259 negative regulation of Rho GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0090284 positive regulation of protein glycosylation in Golgi
GO:0090303 positive regulation of wound healing
GO:2000114 regulation of establishment of cell polarity
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0016363 nuclear matrix
GO:0030532 small nuclear ribonucleoprotein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000067851
View Gene Order
ENSBTAG00000014691
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.638198 Hs.656902
RefSeq NM_006421 XM_005251134 XM_005251135 XM_005251136 XM_006716418
HUGO
OMIM
CCDS CCDS6199
HPRD 09163
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca