InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LTC4S

Summary

InnateDB Gene

IDBG-243666.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTC4S

Gene Name

leukotriene C4 synthase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000213316

Encoded Proteins

IDBP-61662

leukotriene C4 synthase

IDBP-294702

leukotriene C4 synthase

IDBP-477522

leukotriene C4 synthase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:179793980-179796647

Strand

Forward strand

Band

q35.3

Transcripts

ENST00000292596	ENSP00000292596
ENST00000401985	ENSP00000385627
ENST00000465572
ENST00000505170	ENSP00000427299
ENST00000466071
ENST00000486713
ENST00000510544
ENST00000509898

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004464	leukotriene-C4 synthase activity
GO:0004602	glutathione peroxidase activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008289	lipid binding

Biological Process

GO:0006691	leukotriene metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0019372	lipoxygenase pathway
GO:0043085	positive regulation of catalytic activity
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:2001300	lipoxin metabolic process

Cellular Component

GO:0005635	nuclear envelope
GO:0005640	nuclear outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle