InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AREG

Summary

InnateDB Gene

IDBG-24392.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AREG

Gene Name

amphiregulin

Synonyms

AR; AREGB; CRDGF; SDGF

Species

Homo sapiens

Ensembl Gene

ENSG00000109321

Encoded Proteins

IDBP-238932

amphiregulin

IDBP-477086

amphiregulin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:74445134-74455009

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000395748	ENSP00000379097
ENST00000502307	ENSP00000421414
ENST00000511560

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0014009	glial cell proliferation
GO:0014070	response to organic cyclic compound
GO:0031175	neuron projection development
GO:0032355	response to estradiol
GO:0042327	positive regulation of phosphorylation
GO:0042542	response to hydrogen peroxide
GO:0043434	response to peptide hormone
GO:0045668	negative regulation of osteoblast differentiation
GO:0045740	positive regulation of DNA replication
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0060598	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060744	mammary gland branching involved in thelarche
GO:0060749	mammary gland alveolus development
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0016021	integral component of membrane

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

hsa04012

ErbB signaling pathway pathway

INOH

INOH website

GPCR signaling pathway

PID NCI

erbb_network_pathway

ErbB receptor signaling network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.270833

RefSeq

NM_001657

HUGO

OMIM

CCDS

CCDS3565

HPRD

00093

IMGT

EMBL

GenPept

RNA Seq Atlas