Version 5.4
Homo sapiens Gene: ERBB2IP
Summary
InnateDB Gene IDBG-24405.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERBB2IP
Gene Name erbb2 interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112851
Encoded Proteins
IDBP-24409
erbb2 interacting protein
IDBP-24411
erbb2 interacting protein
IDBP-24415
erbb2 interacting protein
IDBP-24419
erbb2 interacting protein
IDBP-369260
erbb2 interacting protein
IDBP-476282
erbb2 interacting protein
IDBP-478224
erbb2 interacting protein
IDBP-484015
erbb2 interacting protein
IDBP-477811
erbb2 interacting protein
IDBP-474761
erbb2 interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16203728
ERBB2IP ccts as a negative regulator of the MDP-mediated activation of NF-kappaB by NOD2.
PMID 16203728
ERBB2IP overexpression inhibits NOD2-dependent cytokine secretion in mouse embryonic fibroblasts.
Entrez Gene
Summary This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:65926475-66082549
Strand Forward strand
Band q12.3
Transcripts
ENST00000284037 ENSP00000284037
ENST00000380943 ENSP00000370330
ENST00000380938 ENSP00000370325
ENST00000380935 ENSP00000370322
ENST00000416865 ENSP00000397833
ENST00000507490
ENST00000511297 ENSP00000422766
ENST00000506030 ENSP00000426632
ENST00000508515 ENSP00000422015
ENST00000507128
ENST00000515185
ENST00000511671 ENSP00000425728
ENST00000503913
ENST00000512354 ENSP00000423959
ENST00000505822
ENST00000509946
ENST00000506744
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 82 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005176 ErbB-2 class receptor binding
GO:0005178 integrin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0016049 cell growth
GO:0045087 innate immune response (InnateDB)
GO:0045104 intermediate filament cytoskeleton organization
GO:0045175 basal protein localization
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Cellular Component
GO:0005604 basement membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0030056 hemidesmosome
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021709
View Gene Order
ENSBTAG00000000415
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_115755
Signaling by ERBB2 pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.249970 Hs.597241 Hs.618801 Hs.740465
RefSeq NM_001006600 NM_001253697 NM_001253698 NM_001253699 NM_001253701 NM_018695 XM_006714660
HUGO
OMIM
CCDS CCDS34172 CCDS3990 CCDS58951 CCDS58952 CCDS58953 CCDS58954
HPRD 06090
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca