Version 5.4
Homo sapiens Gene: ARNTL2
Summary
InnateDB Gene IDBG-24491.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARNTL2
Gene Name aryl hydrocarbon receptor nuclear translocator-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000029153
Encoded Proteins
IDBP-24493
aryl hydrocarbon receptor nuclear translocator-like 2
IDBP-24495
aryl hydrocarbon receptor nuclear translocator-like 2
IDBP-24497
aryl hydrocarbon receptor nuclear translocator-like 2
IDBP-238583
aryl hydrocarbon receptor nuclear translocator-like 2
IDBP-370512
aryl hydrocarbon receptor nuclear translocator-like 2
IDBP-599761
aryl hydrocarbon receptor nuclear translocator-like 2
IDBP-583848
aryl hydrocarbon receptor nuclear translocator-like 2
IDBP-594869
aryl hydrocarbon receptor nuclear translocator-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:27332854-27425289
Strand Forward strand
Band p11.23
Transcripts
ENST00000266503 ENSP00000266503
ENST00000311001 ENSP00000312247
ENST00000261178 ENSP00000261178
ENST00000395901 ENSP00000379238
ENST00000457040 ENSP00000400185
ENST00000544915 ENSP00000442438
ENST00000546179 ENSP00000438545
ENST00000539558
ENST00000542388 ENSP00000445836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0009649 entrainment of circadian clock
GO:0042753 positive regulation of circadian rhythm
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040187
View Gene Order
ENSBTAG00000011804
Not yet available
Pathways
NETPATH
REACTOME
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_24941
Circadian Clock pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8WYA1
TrEMBL
UniProt Splice Variant
Entrez Gene 56938
UniGene Hs.445447
RefSeq NM_001248005 NM_001248002 NM_001248003 NM_001248004 NM_020183 XM_006719113 XM_006719114
HUGO HGNC:18984
OMIM 614517
CCDS CCDS58222 CCDS58219 CCDS58220 CCDS58221 CCDS8712
HPRD 16507
IMGT
EMBL AB039921 AC068794 AC092829 AF231338 AF231339 AF246960 AF246961 AF246962 AF246963 AF256215 AK296706 BC000172 BC125061 BC125062
GenPept AAF71306 AAF71307 AAG34652 AAH00172 AAI25062 AAI25063 AAL50339 AAL50340 AAL50341 AAL50342 BAB01485 BAH12415
RNA Seq Atlas 56938

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca