Version 5.4
Homo sapiens Gene: RCHY1
Summary
InnateDB Gene IDBG-24524.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RCHY1
Gene Name ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Synonyms ARNIP; CHIMP; PIRH2; PRO1996; RNF199; ZCHY; ZNF363
Species Homo sapiens
Ensembl Gene ENSG00000163743
Encoded Proteins
IDBP-24526
ring finger and CHY zinc finger domain containing 1
IDBP-24528
ring finger and CHY zinc finger domain containing 1
IDBP-477898
ring finger and CHY zinc finger domain containing 1
IDBP-484536
ring finger and CHY zinc finger domain containing 1
IDBP-475201
ring finger and CHY zinc finger domain containing 1
IDBP-477354
ring finger and CHY zinc finger domain containing 1
IDBP-482635
ring finger and CHY zinc finger domain containing 1
IDBP-474126
ring finger and CHY zinc finger domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including TP53, HDAC1 and CDKN1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:75479037-75514764
Strand Reverse strand
Band q21.1
Transcripts
ENST00000324439 ENSP00000321239
ENST00000380840 ENSP00000370220
ENST00000514589
ENST00000505105 ENSP00000424631
ENST00000512567
ENST00000504085 ENSP00000421958
ENST00000512706 ENSP00000423976
ENST00000513257 ENSP00000421084
ENST00000507014 ENSP00000424472
ENST00000513909 ENSP00000427205
ENST00000505514
ENST00000513083
ENST00000514021
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 97 [view]
Protein-Protein 96 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051865 protein autoubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029397
View Gene Order
ENSBTAG00000007189
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
p53regulationpathway
p53 pathway
p73pathway
p73 transcription factor network
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001009922 NM_001278536 NM_001278537 NM_001278538 NM_001278539 NM_015436 XM_006714174
HUGO
OMIM
CCDS CCDS34012 CCDS3567 CCDS63990 CCDS63991 CCDS63992
HPRD 07607
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca