InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCNA1

Summary

InnateDB Gene

IDBG-24529.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNA1

Gene Name

cyclin A1

Synonyms

CT146

Species

Homo sapiens

Ensembl Gene

ENSG00000133101

Encoded Proteins

IDBP-24531

cyclin A1

IDBP-365002

cyclin A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:36431830-36442882

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000255465	ENSP00000255465
ENST00000440264	ENSP00000400666
ENST00000463403

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	70 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0051726	regulation of cell cycle