InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KIF22

Summary

InnateDB Gene

IDBG-24634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF22

Gene Name

kinesin family member 22

Synonyms

A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2; SEMDJL2

Species

Homo sapiens

Ensembl Gene

ENSG00000079616

Encoded Proteins

IDBP-24636

kinesin family member 22

IDBP-227529

kinesin family member 22

IDBP-751161

IDBP-746024

IDBP-754685

IDBP-745904

IDBP-749344

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:29790719-29805385

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000160827	ENSP00000160827
ENST00000400751	ENSP00000383562
ENST00000561482	ENSP00000454957
ENST00000570173	ENSP00000455702
ENST00000568312	ENSP00000460077
ENST00000563263
ENST00000569382	ENSP00000456165
ENST00000569636	ENSP00000457176
ENST00000565736
ENST00000563666

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	12 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0006281	DNA repair
GO:0007018	microtubule-based movement
GO:0007067	mitotic nuclear division
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0000776	kinetochore
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005925	focal adhesion

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030677

View Gene Order

ENSBTAG00000013669

Not yet available

Pathways

NETPATH

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_25201

Kinesins pathway

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H3BQB9

UniProt Splice Variant

Entrez Gene

3835

UniGene

Hs.612151 Hs.707242

RefSeq

NM_001256269 NM_001256270 NM_007317

HUGO

HGNC:6391

OMIM

603213

CCDS

CCDS10653 CCDS58444

HPRD

04445

IMGT

EMBL

AC009133

GenPept

RNA Seq Atlas

3835