Version 5.4
Homo sapiens Gene: SREK1
Summary
InnateDB Gene IDBG-24671.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SREK1
Gene Name splicing regulatory glutamine/lysine-rich protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000153914
Encoded Proteins
IDBP-24673
splicing regulatory glutamine/lysine-rich protein 1
IDBP-24675
splicing regulatory glutamine/lysine-rich protein 1
IDBP-480380
splicing regulatory glutamine/lysine-rich protein 1
IDBP-478559
splicing regulatory glutamine/lysine-rich protein 1
IDBP-483316
splicing regulatory glutamine/lysine-rich protein 1
IDBP-477133
splicing regulatory glutamine/lysine-rich protein 1
IDBP-811758
splicing regulatory glutamine/lysine-rich protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:66139971-66183615
Strand Forward strand
Band q12.3
Transcripts
ENST00000380918 ENSP00000370305
ENST00000334121 ENSP00000334538
ENST00000284041
ENST00000521691 ENSP00000428272
ENST00000523851
ENST00000520058
ENST00000522912 ENSP00000427935
ENST00000520953 ENSP00000428970
ENST00000524111
ENST00000518110
ENST00000520580
ENST00000519259
ENST00000523655 ENSP00000430894
ENST00000522214
ENST00000519205
ENST00000612404 ENSP00000481430
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
Experimentally validated
Total 73 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000032621
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.49367 Hs.618889 Hs.619992 Hs.665606 Hs.707830 Hs.717846 Hs.717970
RefSeq NM_001077199 NM_001270492 NM_001270493 NM_139168 XM_005248439 XM_005248440 XM_005248442 XM_006714535
HUGO
OMIM
CCDS CCDS3991 CCDS43323 CCDS75253
HPRD 18043
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca