InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NUP62

Summary

InnateDB Gene

IDBG-246910.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP62

Gene Name

nucleoporin 62kDa

Synonyms

IBSN; p62; SNDI

Species

Homo sapiens

Ensembl Gene

ENSG00000213024

Encoded Proteins

IDBP-63780

nucleoporin 62kDa

IDBP-383583

nucleoporin 62kDa

IDBP-383585

nucleoporin 62kDa

IDBP-762711

IDBP-765948

IDBP-762578

IDBP-760220

IDBP-763038

IDBP-766002

IDBP-764572

IDBP-765137

IDBP-763624

IDBP-759888

IDBP-764074

IDBP-765067

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:49906825-49929763

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000352066	ENSP00000305503
ENST00000422090	ENSP00000407331
ENST00000413454	ENSP00000387991
ENST00000594673	ENSP00000470157
ENST00000597029	ENSP00000473192
ENST00000595373
ENST00000599788	ENSP00000468884
ENST00000593652	ENSP00000472918
ENST00000601665
ENST00000599560
ENST00000595463
ENST00000598301
ENST00000599567	ENSP00000472081
ENST00000596680	ENSP00000471133
ENST00000597814
ENST00000600935	ENSP00000468839
ENST00000597723	ENSP00000469283
ENST00000595761	ENSP00000468930
ENST00000596437	ENSP00000468842
ENST00000600645	ENSP00000470624
ENST00000600583
ENST00000599830
ENST00000599186
ENST00000596217	ENSP00000471191

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	77 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005487	nucleocytoplasmic transporter activity
GO:0005515	protein binding
GO:0017056	structural constituent of nuclear pore
GO:0030159	receptor signaling complex scaffold activity
GO:0042169	SH2 domain binding
GO:0043130	ubiquitin binding
GO:0046966	thyroid hormone receptor binding
GO:0051425	PTB domain binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0006351	transcription, DNA-templated
GO:0006913	nucleocytoplasmic transport
GO:0007077	mitotic nuclear envelope disassembly
GO:0007166	cell surface receptor signaling pathway
GO:0007569	cell aging
GO:0008219	cell death
GO:0008285	negative regulation of cell proliferation
GO:0008645	hexose transport
GO:0009755	hormone-mediated signaling pathway
GO:0009966	regulation of signal transduction
GO:0010827	regulation of glucose transport
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043069	negative regulation of programmed cell death
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407	negative regulation of MAP kinase activity
GO:0044281	small molecule metabolic process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046578	regulation of Ras protein signal transduction
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051028	mRNA transport
GO:0055085	transmembrane transport

Cellular Component

GO:0000922	spindle pole
GO:0005635	nuclear envelope
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0031074	nucleocytoplasmic shuttling complex
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0046930	pore complex