InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HNRNPM

Summary

InnateDB Gene

IDBG-24810.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPM

Gene Name

heterogeneous nuclear ribonucleoprotein M

Synonyms

CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4; HTGR1; NAGR1

Species

Homo sapiens

Ensembl Gene

ENSG00000099783

Encoded Proteins

IDBP-24812

heterogeneous nuclear ribonucleoprotein M

IDBP-24814

heterogeneous nuclear ribonucleoprotein M

IDBP-763557

IDBP-763585

IDBP-762993

IDBP-764263

IDBP-764889

IDBP-763419

IDBP-762277

IDBP-761508

IDBP-765122

IDBP-811370

heterogeneous nuclear ribonucleoprotein M

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:8444767-8489114

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000325495	ENSP00000325376
ENST00000348943	ENSP00000325732
ENST00000596984	ENSP00000470017
ENST00000596295	ENSP00000472599
ENST00000598367	ENSP00000469906
ENST00000597813
ENST00000602219
ENST00000598999	ENSP00000469681
ENST00000601645	ENSP00000471339
ENST00000598603
ENST00000600092	ENSP00000470932
ENST00000600806	ENSP00000471530
ENST00000597081
ENST00000593293
ENST00000594907	ENSP00000472789
ENST00000597270	ENSP00000470635
ENST00000620401	ENSP00000483715

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 243 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	243 [view]
Protein-Protein	243 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0042382	paraspeckles
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000059208

View Gene Order

ENSBTAG00000021039

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.465808 Hs.608878

RefSeq

NM_001297418 NM_005968 NM_031203 XM_005272482

HUGO

OMIM

CCDS

CCDS12203 CCDS12204

HPRD

01188

IMGT

EMBL

GenPept

RNA Seq Atlas