InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MVP

Summary

InnateDB Gene

IDBG-24815.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MVP

Gene Name

major vault protein

Synonyms

LRP; VAULT1

Species

Homo sapiens

Ensembl Gene

ENSG00000013364

Encoded Proteins

IDBP-24817

major vault protein

IDBP-239737

major vault protein

IDBP-748871

IDBP-750310

IDBP-752482

IDBP-748287

IDBP-746854

IDBP-750944

IDBP-749236

IDBP-751768

IDBP-750114

IDBP-749191

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:29820394-29848039

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000357402	ENSP00000349977
ENST00000395353	ENSP00000378760
ENST00000568068
ENST00000562463	ENSP00000457734
ENST00000563096
ENST00000566066	ENSP00000455186
ENST00000570234	ENSP00000456291
ENST00000566554
ENST00000565164	ENSP00000454819
ENST00000569612
ENST00000570061
ENST00000563558	ENSP00000454825
ENST00000563123	ENSP00000458583
ENST00000569887	ENSP00000455532
ENST00000563915	ENSP00000455819
ENST00000566252	ENSP00000457685
ENST00000566859	ENSP00000455741
ENST00000565830

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.

Experimentally validated
Total	79 [view]
Protein-Protein	77 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0008283	cell proliferation
GO:0015031	protein transport
GO:0023057	negative regulation of signaling
GO:0031953	negative regulation of protein autophosphorylation
GO:0038127	ERBB signaling pathway
GO:0051028	mRNA transport
GO:0061099	negative regulation of protein tyrosine kinase activity
GO:0072376	protein activation cascade

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030681

View Gene Order

ENSBTAG00000007952

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.600748 Hs.632177

RefSeq

NM_005115 NM_017458

HUGO

OMIM

CCDS

CCDS10656

HPRD

05475

IMGT

EMBL

GenPept

RNA Seq Atlas