Homo sapiens Gene: ITSN1 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-2505.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | ITSN1 | ||||||||||||||||||||||||
Gene Name | intersectin 1 (SH3 domain protein) | ||||||||||||||||||||||||
Synonyms | ITSN; SH3D1A; SH3P17 | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000205726 | ||||||||||||||||||||||||
Encoded Proteins |
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
intersectin 1 (SH3 domain protein)
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 21:33642400-33899861 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | q22.11 | ||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
NRAGE signals death through JNK pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Developmental Biology pathway
Signalling by NGF pathway
EPHB-mediated forward signaling pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
Axon guidance pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EPH-Ephrin signaling pathway
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KEGG | |||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||
PID NCI |
Internalization of ErbB1
EPHB forward signaling
Regulation of CDC42 activity
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Cross-References | |||||||||||||||||||||||||
SwissProt | Q15811 | ||||||||||||||||||||||||
TrEMBL | C9J1A4 C9JXS9 D6PAW2 Q86VI9 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 6453 | ||||||||||||||||||||||||
UniGene | Hs.160324 Hs.731910 Hs.90221 | ||||||||||||||||||||||||
RefSeq | NM_001001132 NM_003024 XM_005261026 XM_005261027 XM_005261031 | ||||||||||||||||||||||||
HUGO | HGNC:6183 | ||||||||||||||||||||||||
OMIM | 602442 | ||||||||||||||||||||||||
CCDS | CCDS33545 CCDS33546 | ||||||||||||||||||||||||
HPRD | 03898 | ||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AF064243 AF064244 AF064245 AF064246 AF064247 AF114487 AF114488 AF180522 AK300274 AP000308 AP000309 AP000310 AP000311 AP000312 AP000313 AY254341 BC116186 BC117560 DQ386455 DQ679754 DQ679756 DQ679757 EU117382 EU120733 EU120734 EU120735 EU140799 EU140800 EU152331 GU939621 U61166 | ||||||||||||||||||||||||
GenPept | AAC50592 AAC78610 AAC78611 AAC80437 AAD29952 AAD29953 AAD53183 AAI16187 AAI17561 AAP13099 ABD72328 ABG74695 ABG74697 ABG74698 ABV21755 ABV24866 ABV24867 ABV24868 ABV58335 ABV58336 ABV69555 ADF97297 BAG62034 | ||||||||||||||||||||||||
RNA Seq Atlas | 102724664 6453 | ||||||||||||||||||||||||