Version 5.4
Mus musculus Gene: March2
Summary
InnateDB Gene IDBG-251885.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol March2
Gene Name membrane-associated ring finger (C3HC4) 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000079557
Encoded Proteins
IDBP-167584
membrane-associated ring finger (C3HC4) 2
IDBP-626545
membrane-associated ring finger (C3HC4) 2
IDBP-626547
membrane-associated ring finger (C3HC4) 2
IDBP-626548
membrane-associated ring finger (C3HC4) 2
IDBP-626549
membrane-associated ring finger (C3HC4) 2
IDBP-626550
membrane-associated ring finger (C3HC4) 2
IDBP-626551
membrane-associated ring finger (C3HC4) 2
IDBP-626552
membrane-associated ring finger (C3HC4) 2
IDBP-626553
membrane-associated ring finger (C3HC4) 2
IDBP-788806
membrane-associated ring finger (C3HC4) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099785:
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:33685692-33718670
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000066121 ENSMUSP00000065225
ENSMUST00000172934 ENSMUSP00000134026
ENSMUST00000167611 ENSMUSP00000127601
ENSMUST00000173015 ENSMUSP00000133802
ENSMUST00000172767 ENSMUSP00000134220
ENSMUST00000173454 ENSMUSP00000133940
ENSMUST00000173329 ENSMUSP00000133825
ENSMUST00000174040 ENSMUSP00000134437
ENSMUST00000173392 ENSMUSP00000134255
ENSMUST00000186022 ENSMUSP00000139724
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0016567 protein ubiquitination
Cellular Component
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000099785
View Gene Order
ENSBTAG00000021036
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.374865 Mm.490729
RefSeq NM_001252480 NM_145486
OMIM
CCDS CCDS28627 CCDS57064
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca