Version 5.4
Homo sapiens Gene: CXCL10
Summary
InnateDB Gene IDBG-25212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL10
Gene Name chemokine (C-X-C motif) ligand 10
Synonyms C7; crg-2; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10
Species Homo sapiens
Ensembl Gene ENSG00000169245
Encoded Proteins
IDBP-25214
chemokine (C-X-C motif) ligand 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21124994
CXCL10 exert direct antimicrobial effects in vitro against Bacillus anthracis spore and bacilli in a receptor-independent manner and contributes to pulmonary innate immunity. (Demonstrated in murine model)
PMID 21518789
CXCL10 concentration in blood increases during neonatal polymicrobial sepsis, and the blockade of CXCL10 not only worsens recruitment and phagocytic function of macrophages, but also the survival of neonatal mice. (Demonstrated in murine model)
PMID 23998932
MIR21 inhibition enhances CCL5 (RANTES) and CXCL10 (IP-10) release in MCF-7 cancer cells and resulted in increased lymphocyte migration . PIAS3 is a target of MIR21 in MCF-7 cells.
PMID 24448099
ISG15 does not directly alter human rhinovirus replication but modulates immune signalling via the viral sensor protein DDX58 to impact production of CXCL10, which has been linked to innate immunity to viruses.
PMID 24448099
Human rhinovirus infection of epithelial cells induces the expression and secretion of ISG15, which modulates immune responses via effects on DDX58, and by regulating CXCL10 production.
InnateDB Annotation from Orthologs
Summary
PMID 21124994
[Mus musculus] Cxcl10 exert direct antimicrobial effects in vitro against Bacillus anthracis spore and bacilli in a receptor-independent manner and contributes to pulmonary innate immunity.
PMID 21518789
[Mus musculus] Cxcl10 concentration in blood increases during neonatal polymicrobial sepsis, and the blockade of Cxcl10 not only worsens recruitment and phagocytic function of macrophages, but also the survival of neonatal mice.
PMID 26305961
[Mus musculus] Nlrp3 deficiency protects mice from the development of type 1 diabetes by suppressing Th1 responses and impairing T-cell migration to pancreatic islets through the down-regulation of chemokine expression (Ccl5, Cxcl10, Irf1) in islets.
Entrez Gene
Summary This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Jul 2008]
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:76021117-76023497
Strand Reverse strand
Band q21.1
Transcripts
ENST00000306602 ENSP00000305651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 11 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0048248 CXCR3 chemokine receptor binding
Biological Process
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007517 muscle organ development
GO:0008015 blood circulation
GO:0008284 positive regulation of cell proliferation
GO:0009306 protein secretion
GO:0009409 response to cold
GO:0009615 response to virus
GO:0010332 response to gamma radiation
GO:0010818 T cell chemotaxis
GO:0010996 response to auditory stimulus
GO:0016525 negative regulation of angiogenesis
GO:0030335 positive regulation of cell migration
GO:0030816 positive regulation of cAMP metabolic process
GO:0032496 response to lipopolysaccharide
GO:0033280 response to vitamin D
GO:0034605 cellular response to heat
GO:0042127 regulation of cell proliferation
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045087 innate immune response (InnateDB)
GO:0045859 regulation of protein kinase activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051607 defense response to virus
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034855
View Gene Order
ENSBTAG00000001725
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
cxcr3pathway
CXCR3-mediated signaling events
Cross-References
SwissProt P02778
TrEMBL A0A024RDA4
UniProt Splice Variant
Entrez Gene 3627
UniGene Hs.632586
RefSeq NM_001565
HUGO HGNC:10637
OMIM 147310
CCDS CCDS43240
HPRD
IMGT
EMBL BC010954 CH471057 X02530
GenPept AAH10954 CAA26370 EAX05772 EAX05773
RNA Seq Atlas 3627

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca