Version 5.4
Homo sapiens Gene: RNASE7
Summary
InnateDB Gene IDBG-2528.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASE7
Gene Name ribonuclease, RNase A family, 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165799
Encoded Proteins
IDBP-2530
ribonuclease, RNase A family, 7
IDBP-590424
ribonuclease, RNase A family, 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25712218
RNASE7 is produced by airway epithelial basal cells in response to cigarette smoke exposure.
PMID 25637949
DEFB103A and RNASE7 are induced in human umbilical endothelial cells (HUVECs) by classical inflammatory cytokines such as: IFNG, IL1B and TNF.
Entrez Gene
Summary RNASE7 is a member of the RNase A superfamily that has broad-spectrum antimicrobial activity and ribonuclease activity (Harder and Schroder, 2002 [PubMed 12244054]; Zhang et al., 2003 [PubMed 12527768]).[supplied by OMIM, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:21042226-21044234
Strand Forward strand
Band q11.2
Transcripts
ENST00000298690 ENSP00000298690
ENST00000481538 ENSP00000431382
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0003676 nucleic acid binding
GO:0004540 ribonuclease activity
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
GO:0042834 peptidoglycan binding
Biological Process
GO:0009617 response to bacterium
GO:0019731 antibacterial humoral response
GO:0045087 innate immune response (InnateDB)
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0051673 membrane disruption in other organism
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9H1E1
TrEMBL
UniProt Splice Variant
Entrez Gene 84659
UniGene
RefSeq NM_032572
HUGO HGNC:19278
OMIM 612484
CCDS CCDS41914
HPRD
IMGT
EMBL AJ131212 AJ306608 AJ306609 AJ306610 AL161668 AY170392 AY359097 BC074960 BC112334
GenPept AAH74960 AAI12335 AAO12510 AAQ89455 CAC20410 CAC84457 CAC84458 CAC84462
RNA Seq Atlas 84659

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca